Chile, Peru & Panama from San Antonio with Santiago Stay, 27 February 2026 (17 nights)

Served primarily by San Antonio, a moderately-sized Chilean port city within touching distance of the nation’s capital, Santiago is among the highlights on your cruise through South America. The largest city in Chile, and among the largest in the Americas, this urban centre is a fascinating place to explore. From impressive cultural landmarks like La Moneda Palace and San Cristobal Hill to the breathtaking views from atop Santa Lucia Hill and the remarkable artwork in the National Museum of Fine Arts, there are experiences everyone can enjoy in Santiago – not to mention the abundance of incredible restaurants and bars to check out. You’ll also find yourself a stone’s throw from a stretch of stunning beaches in San Sebastian, and San Antonio itself is a fantastic place to spend some time if you’re looking to connect with the great outdoors. So, no matter what type of traveller you are, you’ll find something to enjoy when visiting Santiago.

A coastal city situated in the north of Chile, Iquique features a blend of historic and modern architecture and lots of attractions to visit; including a 19th century clock tower that's located within Arturo Prat Square. Other top highlights in Iquique include the Corbeta Esmeralda Museum and Playa Cavancha beach.

A unique port city in northern Chile, Arica is a popular spot for surfing and watersports, with welcoming turquoise waters off the curved Playa Las Machas and Playa Chinchorror beaches. You’ll also find calmer waters more suitable to swimmers and kayaking in this city’s southern beaches, Playa La Lisera and Playa Brava to name a couple of examples. Beyond this, while the beaches are also fantastic for sun lounging when the weather is warm, Arica has a lot more to offer visitors. Chile’s northernmost city and a literal stone’s throw from the nation’s border with Peru, the culture and cuisine you’ll find in Arica is unique; and, with the city itself sitting in the point where the Azapa Valley and Lluta River converge – both of which cut through the Atacama Desert, the landscapes here are dramatically different to what you would see further south in Chile. Surrounded by rewarding hiking routes, it’s a fantastic place to stretch your legs when you disembark. A fascinating destination ideal for travellers who want to connect more actively with the great outdoors, Arica is an interesting port of call on South American cruises.

Callao is a charming seaside city in Peru, just a short distance from the nation’s capital, home to stunning sandy beaches (primarily on the La Punta peninsula), a vibrant culture, flavourful Peruvian food, and an extensive naval history. As a vital Spanish settlement throughout the colonial era, and a city home to Peru’s main airport and seaport, there is just so much to discover and enjoy when you travel to this bustling urban centre. However, with Lima so close, tours to the Peruvian capital are a must when visiting. An incredible city brimming with culture and history, you’ll find all the modern comforts of a capital here alongside fascinating landmarks, intriguing museums, and more. Whether you’re looking for a quieter visit, soaking in the atmosphere of the city while you wander its history-rich streets, or something a little more lively with boutique shopping and bars where there’s always a party, Lima has it all.